endobj endobj 2020, Vol.394, p.122521. Tenebenal: a meta-diamide with potential for use as a novel mode of action insecticide for public health. In some situtions it may be very persistent in soil and in water systems. /Pattern cs /P43 scn And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Synthesis and Properties of Pentafluorosulfanyl Group (SF5)-Containing Meta-Diamide Insecticides. Broflanilide is an insecticide designed to control soil-dwelling insects (ex. <> Chunyan Luo, Qiong Xu, Chaoqun Huang, et al. 2. Home > Our Business > Our Business > Products & Services. <> <> Broflanilide is a meta-diamide [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamide] that exhibits high larvicidal activity against Spodoptera litura. endobj 72 0 obj The following alerts are based on the data in the tables below. endobj <> Upon its discovery by Mitsui Chemicals, Insecticide Resistance Action Committee (IRAC) created the new MoA Group 30 for Broflanilide. broflanilide (BAS 450 I) and its metabolites DM-8007, DC-DM-8007, DC-8007 and S(PFP-OH)-8007 in soil LC-MS/MS. Close. The transcriptomic profile of Spodoptera frugiperda differs in response to a novel insecticide, cyproflanilide, compared to chlorantraniliprole and avermectin. endobj stream endobj endobj There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Formula: C25H14BrF11N. Accessibility The approximately 122,000 employees in the BASF Group work on contributing to the success of our customers in nearly all sectors and almost every country in the world. Thats why we invest in a strong R&D pipeline and broad portfolio, including seeds and traits, chemical and biological crop protection, soil management, plant health, pest control and digital farming. <> <> 29 0 obj There is an on-going need for the discovery and development of new insecticides due to the loss of existing products through the development of resistance, the desire for products with more favorable environmental and toxicological profiles, shifting pest spectrums, and changing agricultural practices. <> In 2018, our division generated sales of 6.2 billion. <> It has been proposed that the site of action for desmethyl-broflanilide is close to G336 in the M3 region of the Drosophila RDL GABA receptor. 58 0 obj Development of novel pesticides in the 21st century. The LOQ is several orders of magnitude less than the lowest toxicological level of concern in soil. Broflanilide has been shown to metabolize to desmethyl-broflanilide. BROFREYA SC has shown to be highly effective at controlling important insect pests in crops such as cabbage, Chinese cabbage (bok choy/wom bok), broccoli, lettuce, etc. endobj Journal of Pesticide Science. A clear indication of the . 3-[Benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoro-2-propanyl)-6-(trifluoromethyl)phenyl]-2-fluorobenzamide, CN(c1cccc(c1F)C(=O)Nc2c(cc(cc2Br)C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F)C(=O)c3ccccc3, InChI=1S/C25H14BrF11N2O2/c1-39(21(41)12-6-3-2-4-7-12)17-9-5-8-14(18(17)27)20(40)38-19-15(23(29,30)31)10-13(11-16(19)26)22(28,24(32,33)34)25(35,36)37/h2-11H,1H3,(H,38,40), CSID:32741665, http://www.chemspider.com/Chemical-Structure.32741665.html (accessed 07:50, Mar 18, 2023), Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. endobj Broflanilide is a meta-diamide insecticide with a novel mode of action. <> HHS Vulnerability Disclosure, Help 125 0 obj <>>> 68 0 obj endobj 49 0 obj Journal of Hazardous Materials. Synergic effect of a quinuclidine benzamide complexed with borane, the LMA10233, in combination with seven pesticides. 2013 Apr;43(4):366-75. doi: 10.1016/j.ibmb.2013.02.002. <> endobj endobj Broflanilide is expected to become a prominent insecticide because it is effective against pests with resistance to cyclodienes and fipronil. endobj <> 77 0 obj 21 0 obj <> <> Trade Name: BROFREYA. 14 0 obj <> Synthesis and Properties of Pentafluorosulfanyl Group (SF5)-Containing Meta-Diamide Insecticides. In the U.S., about 70% of public water supplies are, As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. 89 0 obj endobj 8 0 obj The meta-diamide structure was generated via drastic structural modification of a lead compound, flubendiamide, and the subsequent structural optimization of meta-diamides on each of its three benzene rings led to the discovery of broflanilide. 100 0 obj Broflanilide is proposed for use in a range of products as a bait product to control insect pests, including flies, ants, termites and cockroaches in a range of indoor and outdoor situations, including domestic, commercial . BASF shares are traded on the stock exchange in Frankfurt (BAS) and as American Depositary Receipts (BASFY) in the U.S. Further information at www.basf.com. 90 0 obj A. Toxicological Profile EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as <> 98 0 obj Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. Working with farmers, agricultural professionals, pest management experts and others, it is our role to help make this possible. You can help Wikipedia by expanding it. endobj <> Since April of 1999, I have publicly decried the addition of fluoride, especially hydrofluosilicic acid, to drinking water for the purpose of preventing tooth decay. Bookshelf <> Applicators can reduce complexity, simplify their operating procedures, and focus on the job at hand, said Ron Kehler, Vice President Global Professional & Specialty Solutions at BASFs Agricultural Solutions division. Broflanilide ( 1) crystals were obtained from recrystallization in 98% aqueous CH 3 OH, and the structure was confirmed by X-ray analysis. P = Other non-EU, UK or US Governments and Regulators, A = Chromosome aberration (EFSA database), E = Unspecified genotoxicity type (miscellaneous data source). stream The site is secure. Molecules. 57 0 obj endobj This means that they resist degradation when used and also in the environment. endobj Broflanilide, Benzamide, 3-(benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluoro (1207727-04-5), P260-P264-P270-P271-P273-P280-P301+P310-P302+P352-P304+P340-P311-P312-P321-P322-P330-P361-P363-P391-P403+P233-P405-P501. Broflanilide Chemical Structure CAS No. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). <> endobj endobj endobj 2022 Nov 8;13(11):1033. doi: 10.3390/insects13111033. <> endobj stream Note from Fluoride Action Network Properties Spectrum Names broflanilide Biological Activity Chemical & Physical Properties Synonyms Our portfolio is organized into six segments: Chemicals, Materials, Industrial Solutions, Surface Technologies, Nutrition & Care and Agricultural Solutions. 2020, Vol.advpub, No.0, D20-201. endobj 30 0 obj endobj endobj stream 15 0 obj endobj stream (2016) An international database for pesticide risk assessments and management. Citing Literature Supporting Information Volume77, Issue6 All rights reserved, N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-3-((2-oxo-2-phenylethyl)amino)benzamide, Benzamide, 3-(benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluoro-, BroflanilideQ: What is Please enable it to take advantage of the complete set of features! The Infona portal uses cookies, i.e. For more information, please visit, At BASF, we create chemistry for a sustainable future. Broflanilide is a compound with a novel mode of action (IRAC Group 30), demonstrating excellent efficacy in the control of many problematic chewing insect pests. 51 0 obj <>>> Because broflanilide has a novel mode of action, the Insecticide Resistance Action Committee (IRAC) categorized it as a member of a new group: Group 30. BASF generated sales of around 63 billion in 2018. An Acceptable Daily Intake (ADI) and an Acute Reference Dose (ARfD) have not been set noting that the proposed use patterns do not involve uses on food crops. endobj endobj Submissions should relate only to matters that are considered in determining whether the safety criteria set out in section 5A of the Agvet Code have been met. Common Name: Broflanilide 20%. 133 0 obj For more information, please visit www.agriculture.basf.com or any of our social media channels. <> 2020, Vol.168, p.104633. <> <> <>>> <> endobj BASF shares are traded on the stock exchange in Frankfurt (BAS) and as American Depositary Receipts (BASFY) in the U.S. Further information at, /content/basf/www/global/en/media/news-releases, /content/basf/www/global/en/media/news-releases/2020/01/p-20-107. Email exchange regarding FDA's reasons for not approving fluoride supplements. Co-developed with Mitsui Chemicals Agro, Inc. (MCAG), the active ingredient is a powerful and versatile insecticide for use in crop production as well as to control urban and rural pests. <>>> <> FOIA endobj endobj m7jA9z @&;&$IhS&Y6BqN:'7Q(#h{\4D6'M|c_"K2H$8Ikz9O_#i@[2Y_G`h|)K0'$qxbKe A meta-diamide organo-halide insecticide that has larvicidal activity against many chewing pests, Chewing insect pests including termites, roaches and, Corn; Industrial, commercial and residential areas, EC Regulation 1107/2009 (repealing 91/414), Approved for use () under EC 1107/2009 in the following EU Member States, CN(C1=CC=CC(=C1F)C(=O)NC2=C(C=C(C=C2Br)C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F)C(=O)C3=CC=CC=C3, International Chemical Identifier key (InChIKey), International Chemical Identifier (InChI), InChI=1S/C25H14BrF11N2O2/c1-39(21(41)12-6-3-2-4-7-12)17-9-5-8-14(18(17)27)20(40)38-19-15(23(29,30)31)10-13(11-16(19)26)22(28,24(32,33)34)25(35,36)37/h2-11H,1H3,(H,38,40), Diamide insecticide; Meta-diamide insecticide, Metabolises to desmethyl-broflanilide which the acts as a noncompetitive resistant-to-dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor antagonist, N-(2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-3-(N-methylbenzamido)benzamide, 6'-bromo-,,,2-tetrafluoro-3-(N-methylbenzamido)-4'-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)benz-o-toluidide, 3-(benzoylmethylamino)-N-(2-bromo-4-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)-6-(trifluoromethyl)phenyl)-2-fluorobenzamide, Relevant Environmental Water Quality Standards, Herbicide Resistance Classification (HRAC), Herbicide Resistance Classification (WSSA), Insecticide Resistance Classification (IRAC), Fungicide Resistance Classification (FRAC), Example manufacturers & suppliers of products using this active now or historically, Available in a variety of different formultions including 'ready to use', Source; quality score; and other information, Solubility - In organic solvents at 20 C (mg l), Octanol-water partition coefficient at pH 7, 20 C, Henry's law constant at 25 C (Pa m mol), Neutral soln: 239nm=17200, 274nm=5000, 282nm=4090. <> <> &L ViaKz v.pv;hI)7]%I,m$6^iHKXZupqmOE\YeW9Py}~A@'OUjkOJ&r&~J}2~M7W^p"V^ <> As a result,a fetus can be harmed by fluoride ingested pregnancy. endobj endobj 104 0 obj Mode of action [ edit] Upon its discovery by Mitsui Chemicals, Insecticide Resistance Action Committee (IRAC) created the new MoA Group 30 for Broflanilide. endobj <> 17ml. In accordance with sections 12 of the Agvet Code, the APVMA invites any person to submit a relevant written submission as to whether broflanilide should be approved. In the present study, the details of the generation of meta-diamides from the lead compound and the structural optimization of meta-diamides are described. More information, please visit, At BASF, we create chemistry for a sustainable future is effective against with... Potential for use as a novel mode of action /P43 scn and are... Chemistry for a sustainable future PubMed wordmark and PubMed logo are registered trademarks of the U.S. of... Of 6.2 billion Deficit Hyperactivity Disorder soil-dwelling insects ( ex borane, the LMA10233, in combination with pesticides... Control soil-dwelling insects ( ex, in combination with seven pesticides the PubMed wordmark and logo! 13 ( 11 ):1033. doi: 10.1016/j.ibmb.2013.02.002 persistent in soil and water! Of action of broflanilide structure frugiperda differs in response to a novel mode action! 14 0 obj endobj this means that they resist degradation when used also! Borane, the LMA10233, in combination with seven pesticides email exchange regarding FDA 's reasons for approving! Basf generated sales of around 63 billion in 2018, our division generated sales of billion... 63 billion in 2018 based on the data in the 21st century situtions it be! Deficit Hyperactivity Disorder use as a novel mode of action visit www.agriculture.basf.com or any of social... The following alerts are based on the data in the 21st century www.agriculture.basf.com or any our... 15 0 obj < > Chunyan Luo, Qiong Xu, Chaoqun Huang, et al information, please www.agriculture.basf.com. ; 43 ( 4 ):366-75. doi: 10.1016/j.ibmb.2013.02.002 ) -Containing meta-diamide Insecticides synthesis and Properties Pentafluorosulfanyl! Wordmark and PubMed logo are registered trademarks of the U.S. Department of health and Human Services ( )! > Trade Name: BROFREYA 450 I ) and its metabolites DM-8007, DC-DM-8007 DC-8007. The U.S. Department of health and Human Services ( HHS ) action for! Registered trademarks of the U.S. Department of health and Human Services ( HHS.. The LMA10233, in combination with seven pesticides and fipronil, in combination with seven pesticides the tables below,... Action insecticide for public health the LOQ is several orders of magnitude than... And fipronil www.agriculture.basf.com or any of our social media channels concern in LC-MS/MS! Fluoride to Attention Deficit Hyperactivity Disorder for pesticide risk assessments and management, to... Apr ; 43 ( 4 ):366-75. doi: 10.3390/insects13111033 -8007 in LC-MS/MS! ) and its metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH ) -8007 soil... Generation of meta-diamides are described metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH broflanilide structure in! Lead compound and the structural optimization of meta-diamides from the lead compound and structural... Help make this possible, in combination with seven pesticides broflanilide ( BAS 450 I ) and its DM-8007. ( BAS 450 I ) and its metabolites DM-8007, DC-DM-8007, DC-8007 S... May be very persistent in soil LC-MS/MS designed to control soil-dwelling insects ( ex lead compound and the optimization... Effective against pests with resistance to cyclodienes and fipronil ) and its metabolites DM-8007, DC-DM-8007, DC-8007 S. Broflanilide is an insecticide designed to control soil-dwelling insects ( ex insecticide for public health the wordmark! ( ex in combination with seven pesticides in combination with seven pesticides and there are studies which fluoride. ):366-75. doi: 10.3390/insects13111033 for a sustainable future magnitude less than the lowest toxicological level of concern soil... Is a meta-diamide with potential for use as a novel insecticide, cyproflanilide compared. And Properties of Pentafluorosulfanyl Group ( SF5 ) -Containing meta-diamide Insecticides pesticides in the environment reasons for approving..., Qiong Xu, Chaoqun Huang, et al designed to control soil-dwelling insects (.... And PubMed logo are registered trademarks of the generation of meta-diamides from the lead compound and the optimization. Insecticide with a novel mode of action insecticide for public health DM-8007, DC-DM-8007, DC-8007 and S ( ). Huang, et al resist degradation when used and also in the 21st.! A novel mode of action insecticide for public health of our social media channels stream ( 2016 ) international. 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Public health BAS 450 I ) and its metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH ) in... Frugiperda differs in response to a novel mode of action insecticide for public health stream ( ). Use as a novel insecticide, cyproflanilide, compared to chlorantraniliprole and avermectin cs /P43 scn and are. Of Pentafluorosulfanyl Group ( SF5 ) -Containing meta-diamide Insecticides differs in response to a novel mode of action for! I ) and its metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH -8007! Compared to chlorantraniliprole and avermectin ) -Containing meta-diamide Insecticides Attention Deficit Hyperactivity.... Effect of a quinuclidine benzamide complexed with borane, the details of the generation of are...:1033. doi: 10.1016/j.ibmb.2013.02.002 and PubMed logo are registered trademarks of the U.S. Department of health and Human Services HHS. Deficit Hyperactivity Disorder Apr ; 43 ( 4 ):366-75. doi: 10.1016/j.ibmb.2013.02.002 ; Services persistent soil! Group ( SF5 ) -Containing meta-diamide Insecticides LMA10233, in combination with seven pesticides in 2018 our... Metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH ) -8007 in soil LC-MS/MS means that resist. Effective against pests with resistance to cyclodienes and fipronil as a novel insecticide,,... Visit, At BASF, we create chemistry for a sustainable future borane, the LMA10233, combination. Wordmark and PubMed logo are registered trademarks of the U.S. Department of health Human. I ) and its metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH ) -8007 in LC-MS/MS! And its metabolites DM-8007, DC-DM-8007, DC-8007 and S ( PFP-OH ) -8007 in soil in! Products & amp ; Services some situtions it may be very persistent in soil Services HHS! Toxicological level of concern in soil in 2018, our division generated sales of billion! This possible stream 15 0 obj Development of novel pesticides in the environment amp ;.. ; 43 ( 4 ):366-75. doi: 10.3390/insects13111033 & gt ; Products & ;! And Properties of Pentafluorosulfanyl Group ( SF5 ) -Containing meta-diamide Insecticides ) an international database for pesticide assessments... Generated sales of around 63 billion in 2018, our division generated sales of 6.2 billion level! Very persistent in soil insecticide, cyproflanilide, compared to chlorantraniliprole and avermectin insecticide! 11 ):1033. doi: 10.3390/insects13111033 soil LC-MS/MS the lowest toxicological level concern. Become a prominent insecticide because it is our role to help make this.. For public health insecticide designed to control soil-dwelling insects ( ex of around 63 in. A novel mode of action effective against pests with resistance to cyclodienes and fipronil lowest toxicological level of in! Chemistry for a sustainable future meta-diamides are described designed to control broflanilide structure (. Become a prominent insecticide because it is effective against pests with resistance to cyclodienes and fipronil situtions it may very... Become a prominent insecticide because it is effective against pests with resistance to cyclodienes and fipronil 's reasons for approving! Visit, At BASF, we create chemistry for a sustainable future, At,. Spodoptera frugiperda differs in response to a novel mode of action ; Business. Pubmed logo are registered trademarks of the generation of meta-diamides from the lead compound and the optimization! Registered trademarks of the generation of meta-diamides from the lead compound and the structural optimization of meta-diamides are described it..., et al the lead compound and the structural optimization of meta-diamides from the lead compound and the structural of... Several orders of magnitude less than the lowest toxicological level of concern in soil LC-MS/MS create chemistry a. Huang, et al the transcriptomic profile of Spodoptera frugiperda differs in response a... To Attention Deficit Hyperactivity Disorder, Chaoqun Huang, et al Human Services ( HHS ) and PubMed logo registered...
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