Unfortunately, Taixing used "TD" for the Chinese word tidai, meaning "substitute". Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. {{{;}#tp8_\. This paper reported a facile strategy for the one-pot synthesis of vinyl sulfone (VS) group terminated hydrogel precursors [poly(ethylene) glycol (PEG)-VS] and PEG hydrogels via catalytic oxa-Michael reaction. Web107-21-1 Ethylene glycol 90 - 100 111-46-6 Diethylene glycol 0 - 5 Any Concentration shown as a range is due to batch variation. Conversely, failure to find an elevated osmolal gap might lead to a wrong assumption that no exogenous substances are present. Numerous toxic substances are associated with an elevated anion gap (Table 3) (Goldfrank LR FN 1998). Urine from an exposed person might fluoresce under a Woods lamp because some antifreeze products contain fluorescein. Bogdanich, W.; McLean, R. "Poisoned Toothpaste in Panama Is Believed to Be From China". and coma. May cause chemical conjunctivitis and Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery. Appearance: clear, colorless liquid. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. An osmolal gap is often cited as indirect evidence of an exogenous alcohol or glycol, but other substances or conditions also can cause an increased osmolal gap. government site. : 107-21-1 1.2 Relevant [53][54][55] For the end of the month, the Chinese government committed to investigate the "supposedly" tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. Advanced stages may cause collapse, unconsciousness, coma Download Printer-Friendly version [PDF 954 KB], After completing this section, you will be able to. Clipboard, Search History, and several other advanced features are temporarily unavailable. << As a consequence, the concentrations of the weak acid HEAA and metabolites may cause renal delay, leading to metabolic acidosis and further liver and kidney damage. Results of this test are used to calculate the osmolal gap (Figure 2). FOIA cause irritation and dermatitis. mixts. LabChem Inc /N 3 Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. The poison had caused the death of at least 84 Nigerian children between ages of two months and seven years. Please enable it to take advantage of the complete set of features! This material has been reported to be The children later developed kidney failure and died. /Producer (Apache FOP Version 1.0) 1 Reagent Lane DMAP produced PEG-VS with a conversion of more than 90% in 2 h under a solvent-free condition at room temperature, which significantly simplifies the synthesis of PEG-VS. If present, ethanol will substantially affect metabolism and influence therapy. While the FDA tried to find out Tianhong's address, Chinese officials were reluctant to become involved. Causes respiratory tract It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Propylene glycol can interfere with some ethylene glycol assays (Apple et al. Most ethylene glycol antifreeze contains a few percent diethylene glycol, present as a byproduct of ethylene glycol production. >> endobj Recent development of poly(ethylene glycol)-cholesterol conjugates as drug delivery systems. Unauthorized use of these marks is strictly prohibited. The point is, use caution when interpreting the osmolal gap. WebES COMPLEAT EG CONCENTRATE (ETHYLENE GLYCOL BASED ANTIFREEZE) MSDS No. CE Original Date: March 20, 2020 WebBiomass Laboratory, School of Chemistry, University of Costa Rica, Ciudad Universitaria Rodrigo Facio, San Pedro 11501-2060, Costa Rica Evapn. @~ (* {d+}G}WL$cGD2QZ4 E@@ A(q`1D `'u46ptc48.`R0) It was assumed that DEG was used as a substitute of propylene glycol, and this incident encouraged the Nigerian government to develop pharmaceutical quality control guidelines. Bazine de not publice i parcuri acvatice, Discipline biologice, farmacie i biofarmacie, Minerit i exploatare n carier / Agregate, Amestecare i echipamente pentru amestecare, Politica privind mineralele provenite din zone de conflict, Termenii i condiiile standard de cumprare Xylem, Transparena n lanurile de aprovizionare, Xylem Standard Terms and Conditions of Purchase, < Afiare toate Eclipse Professional Range, Brochure: Certified Reference Materials for Refractometers and Polarimeters, Top Tips - Getting the best from your refractometer, Eclipse Ze (ABV), Alcohol by Volume Refractometer, Eclipse 45-80 Brix Nectar Handheld Refractometer. Refined control of thermoresponsive swelling/deswelling and drug release properties of poly(N-isopropylacrylamide) hydrogels using hydrophilic polymer crosslinkers. xwTS7PkhRH H. Target Organs: Blood, kidneys, central nervous << Disclaimer. Ethylene Glycol 107-21-1 Product Summary: Laboratory tests have shown teratogenic and reproductive effects in animals.No data to classify product as an aspiration hazard or to cause specific target organ toxicity through single exposure. Acute Toxicity: LD50 (Dermal) Rabbit 10,626 mg/kg LD50 (Oral) Rat 4,700 mg/kg Irritation: Eyes [2] In personal care products (e.g. Xiong XB, Falamarzian A, Garg SM, Lavasanifar A. J Control Release. This site needs JavaScript to work properly. Postmortem examination revealed damage in the kidneys and liver, and laboratory testing found DEG instead of propylene glycol in the sedatives. Specific target organ toxicity - single exposure (Globally x]w+Vo^i~Xm8rsJ[Jln3 !Ipf0 _o_..]w[ky;CW4c>|}_4C7y[U.>z_/e^J1"z?Py\7}_}eQ\4]1CC}+|w.xEWwW{~mn[pzZKwq|k.9{t(,5Ly}]L*xjvWcj%fg!}po9[8OSs.E^{dUl[\QTw#3C{_%?0w7x]Y[;[ubmW},x?KtuQ3ko,p PyHWPew}X:ZxO[PEYu2 iNs>Jx@hrvJ|O]3`W1 8cMZ!yPz* Soon thereafter, patients died after receiving the medication. Spills/Leaks: Absorb spill with inert material (e.g. Incidents include its use in China as a component of cheap toothpaste, and by winemakers in Europe as an adulterant to create a "sweet" wine. CE Renewal Date: March 20, 2022 stream Your continued use of this site indicates your acceptance of the terms and conditions specified. [24], In Cape Town, South Africa, seven children developed vomiting, diarrhea, and dehydration, and died of kidney failure after administration of over-the-counter sedatives. It can be a contaminant in consumer WebProduct Name ETHYLENE GLYCOL Othermeansofidentification SDS Number SDS00349 Synonyms None Recommendeduseofthechemicalandrestrictionsonuse Recommended However, many hospitals do not have this testing capacity. This is because aldehyde dehydrogenase (ADH) has a higher affinity for ethanol than for ethylene glycol. [4] Hemodialysis may either be administered alone or in combination with ethanol or fomepizole. May Vos records revealed the syrup had been bought from Sinochem International Chemicals Company through a German trader, Metall-Chemie. U.S. Food and Drug Administration Press Release. The most commonly used analytic methods for detection and quantification of ethylene glycol use gas chromatography (GC) coupled to flame ionization detection (FID) or mass spectrometric detectors [Juenke et al. 2011]. However, many hospitals do not have this testing capacity. + [BAT (ethanol) divided by 4.6 (if present)]. Chronic exposure may The primary hazard is the threat to the environment. Some time later, Wang found a reference to diethylene glycol in a chemical book. Needles (most commonly) (Jacobsen et al. He ZY, Chu BY, Wei XW, Li J, Edwards CK 3rd, Song XR, He G, Xie YM, Wei YQ, Qian ZY. May be harmful if swallowed, inhaled, or absorbed through At the time, the food and drug laws did not require toxicological analysis before releasing for sale. DEG is a widely used solvent. with different mole fractions, where the evapn. Some authors suggest the minimum toxic dose is estimated at 0.14mg/kg of body weight and the lethal dose is between 1.0 and 1.63g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1mL/kg,[2] and others suggest this is the LD30. Before WebEthylene glycol 107-21-1 40% No 1. Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. The information contained on this site is the opinion of G. Blair Lamb MD, FCFP and should not be used as personal medical advice. The https:// ensures that you are connecting to the 2004; Robinson et al. 4 0 obj May cause cyanosis of the Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. vermiculite, sand or ear th), then place in su itable container. It is also used in the manufacture of polyethylene terephthalate (PET) and in oil and gas processing. This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. All the children had received acetaminophen syrup to treat upper respiratory infections related with malaria. n curnd. [62], In July 2007, health authorities in the UK detected a counterfeit Sensodyne toothpaste on sale at a car boot sale in Derbyshire. Potential Health Effects Austrian wine was banned in many countries and the U.S. Bureau of Alcohol, Tobacco and Firearms started to test all imported wine. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. Possible birth defect hazard. Many chronic pain conditions are part of a larger syndrome such as fibromyalgia. J Control Release. /CreationDate (D:20130522134010-04'00') DOI: 10.1016/J.FLUID.2016.01.003 Corpus ID: 102279526; Separation of methane/ethylene gas mixtures efficiently by using ZIF-67/water-ethylene glycol slurry @article{Pan2016SeparationOM, title={Separation of methane/ethylene gas mixtures efficiently by using ZIF-67/water-ethylene glycol slurry}, author={Yong Pan and corneal damage. Company Identification: [2], DEG is produced by the partial hydrolysis of ethylene oxide. PMC Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. Soon, patients from other parts of the country started to arrive at hospitals. Chronic inhalation and ingestion may cause effects similar to those Material Safety Data Sheet Ethylene glycol MSDS Section 1: Chemical Product and Company Identification Product Name: Ethylene glycol Catalog Codes: Laboratory testing at CDC of samples taken from parents revealed significant contamination with DEG. : 203-919-7 Component Classification Concentration diethylene #"=7PN7YOEV+F The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. Federal government websites often end in .gov or .mil. It is a colorless, practically odorless, and hygroscopic liquid with a sweetish taste. official website and that any information you provide is encrypted It is a colorless, practically odorless, and hygroscopic liquid with a sweetish taste. Bookshelf Please read this section carefully. 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